The Effect of Giving Nanoherbal of Biwa (Eriobotrya japonica (Thunb.) Lindl. (Thunb.) Lindl.) Leaf on the Quality and Quantity of Spermatozoa And Microstructure in Diabetes Rat (Rattus norvegicus) Induced by Alloxan

One of causes in decreasing quantity and quality spermatozoon is disease. Increased blood glucose levels can trigger demage spermatogenesis the testes, thereby reducing spermatozoa production. Biwa leaves (Eriobotrya japonica (Thunb.) Lindl.) contain triterpenes which are expected to overcome cauda epididymis. To investigate this problem, an experimental test nano herbal biwa was carried out a rat model (Rattus norvegicus) diabet. There five treatments six replications, it found that best dose 500 mg/kg body weight could improve so number remained normal. It concluded be used as alternative drug maintain fertility seen from spermatozoa. The result analyzed by ANOVA further Post-Hoc-Test (Duncan). show significant differences (p<0,05) adult white male mouse norvegicus).